Understanding Asthma Using Animal Models
نویسندگان
چکیده
منابع مشابه
Understanding asthma using animal models
Asthma is a complex syndrome with many clinical phenotypes in children and adults. Despite the rapidly increasing prevalence, clinical investigation and epidemiological studies of asthma, the successful introduction of new drugs has been limited due to the different disease phenotypes and ethical issues. Mouse models of asthma replicate many of the features of human asthma, including airway hyp...
متن کاملAnimal models of asthma.
Studies in animal models form the basis for much of our current understanding of the pathophysiology of asthma, and are central to the preclinical development of drug therapies. No animal model completely recapitulates all features of the human disease, however. Research has focused primarily on ways to generate allergic inflammation by sensitizing and challenging animals with a variety of fore...
متن کاملUnderstanding Through Animal Models
Animal models in biomedical research provide an interactive, dynamic system that can be observed and manipulated experimentally in order to promote our understanding of a human condition or disease by elucidating the biological mechanisms underlying normal function and disease. Animal models allow researchers to test hypotheses about the causes and cures of a disorder and to develop effective t...
متن کاملAnimal models of occupational asthma.
Occupational asthma is characterized by variable airflow obstruction occurring in the workplace. The presence of airways inflammation and hyperreactivity provides further evidence for the disease. Since its pathogenic mechanism(s) are unknown, animal models have been developed to investigate the various disease processes, as well as to enable study of environmental and genetic factors which may...
متن کاملAsthma: a comparison of animal models using stereological methods
Asthma is a worldwide health problem that affects 300 million people, as estimated by the World Health Organization. A key question in light of this statistic is: ‘‘what is the most appropriate laboratory animal model for human asthma?’’ The present authors used stereological methods to assess airways in adults and during postnatal development, and their response to inhaled allergens to compare...
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ژورنال
عنوان ژورنال: Allergy, Asthma and Immunology Research
سال: 2009
ISSN: 2092-7355
DOI: 10.4168/aair.2009.1.1.10